 |
Studentská vědecká konference: Současné problémy radiační ochrany obyvatelstva Editor Ing. Yulia Efremova, Ing. Jana Hudzietzová Vydalo České vysoké učení technické v Praze |
 |
Ing. Jiří Halaška, Ph.D., PhDr. Mgr. Rebeka Ralbovská, Ph.D. a kol. Recenzenti: prof. Ing. Gustav Šafr, DrSc., Mgr. Renata Havránková, Ph.D. ČVUT v Praze |
 |
Nové pohledy na neinvazivní laser Pavla Alexandrová, Yulia Efremova, Jana Hercogová, Hana Kolářová, Leonardo Longo, Alexandra Mateřánková, Leoš Navrátil (editor), Václav Navrátil, Pavel Poledňák, Jaroslav Průcha, Eva Remlová, Jozef Rosina Grada Publishing, Praha 2015, ISBN 978-80-247-1651-0
|
|
|
|
 |
Biomedicínská detekce ionizujícího záření Zuzana Šinkorová, Leoš Navrátil České vysoké učení technické v Praze, Česká technika – nakladatelství ČVUT, Praha 2014, ISBN 978-80-01-05626-4
|
|
|
|
 |
Téma: Úloha adenosinových receptorů v regulaci ionizujícím zářením poškozené krvetvorby |
 |
Comparison of the Radiosensitizing Effect of ATR, ATM and DNA-PK Kinase Inhibitors on Cervical Carcinoma Cells
Vávrová J, Zárybnická L, Jošt P, Tichý A, Řezáčová M, Šinkorová Z, Pejchal J.
Folia Biol (Praha). 2016;62(4):167-74.
For full text: jirina.vavrova@unob.cz |
 |
Chromatin dynamics during DSB repair.
Falk M, Lukasova E, Gabrielova B, Ondrej V, Kozubek S.
Biochim Biophys Acta. 2007 Oct;1773(10):1534-45. (IF = 6.9)
In this work we show for the first time, on spatially fixed and live cells, how chromatin structure and nuclear topology influence (or even drive) the mechanism of how chromosomal translocations are formed For full text: falk@ibp.cz |
 |
Chromatin structure influences the sensitivity of DNA to gamma-radiation.
Falk M, Lukášová E, Kozubek S.
Biochim Biophys Acta. 2008 Dec;1783(12):2398-414. (IF = 6.9)
doi: 10.1016/j.bbamcr.2008.07.010.
In this paper we reveal how chromatin structure influences its sensitivity to induction of DNA double strand breaks (DSB) as well as the efficiency of DSB repair For full text: falk@ibp.cz |
 |
Higher-order chromatin structure in DSB induction, repair and misrepair.
Falk M, Lukasova E, Kozubek S.
Mutat Res. 2010 Apr-Jun;704(1-3):88-100. (IF = 7.1)
doi: 10.1016/j.mrrev.2010.01.013. Review.
In this review, supplemented with our results, we discuss on new findings in the field of DNA double strand break induction, repair, and misrepair in the context of higher-order chromatin structure For full text: falk@ibp.cz |
 |
Two New Faces of Amifostine: Protector from DNA Damage in Normal Cells and Inhibitor of DNA Repair in Cancer Cells.
Hofer M, Falk M, Komůrková D, Falková I, Bačíková A, Klejdus B, Pagáčová E, Štefančíková L, Weiterová L, Angelis KJ, Kozubek S, Dušek L, Galbavý Š.
J Med Chem. 2016 Apr 14;59(7):3003-17. (IF = 5.45)
doi: 10.1021/acs.jmedchem.5b01628.
We readdressed the radioprotective effects of amifostine on normal and cancer cells, respectively, by using currently the most sensitive methods to detect and quantify DSBs. For full text: falk@ibp.cz |
 |
Štefančíková L, Lacombe S, Salado D, Porcel E, Pagáčová E, Tillement O, Lux F, Depeš D, Kozubek S, Falk M.
Effect of gadolinium-based nanoparticles on nuclear DNA damage and repair in glioblastoma tumor cells.
J Nanobiotechnology. 2016;14(1):63. doi: 10.1186/s12951-016-0215-8.(IF = 4.24)
Our results suggest that the radiosensitization mediated by GdBNs is a cytoplasmic event that is independent of the nuclear DNA breakage, a phenomenon commonly accepted as the explanation of biological radiation effects. Considering our earlier recognized colocalization of GdBNs with the lysosomes and endosomes, we revolutionary hypothesize here about these organelles as potential targets for (some) nanoparticles. If confirmed, this finding of cytoplasmically determined radiosensitization opens new perspectives of using nano-radioenhancers to improve radiotherapy without escalating the risk of pathologies related to genetic damage. For full text: falk@ibp.cz |
